Sinzinger H, Kaliman J, Mannheimer E
Lymphology. 1986 Jun;19(2):79-81.
Whereas prostaglandin I2 (PGI2), a major metabolite of human lymphatics, does not itself affect lymphatic contractility significantly, it is able to counterbalance the contractile response to thromboxane and leukotrienes. We now demonstrate that leukotrienes C4 and D4 evoke a dose-dependent increased production of PGI2 from human lymphatics. It is likely that leukotrienes either exert a contractile rhythmic effect on human lymphatics or, alternatively, evoke increased PGI2-formation which relaxes human lymphatics. These mechanisms may be of local importance in regulating lymphatic "tone" at sites of inflammation as leukotrienes are liberated from activated white blood cells.
虽然前列腺素I2（PGI2）是人体淋巴管的主要代谢产物，但其本身对淋巴管收缩性并无显著影响，但它能够抵消对血栓素和白三烯的收缩反应。我们现在证明，白三烯C4和D4可引起人体淋巴管中PGI2的生成呈剂量依赖性增加。白三烯可能对人体淋巴管产生收缩性节律效应，或者引起PGI2生成增加，从而使人体淋巴管舒张。由于白三烯是从活化的白细胞中释放出来的，这些机制在调节炎症部位的淋巴管“张力”方面可能具有局部重要性。
