Suckfüll M, Wimmer C, Schorn K, Mees K
Klinik für Hals-, Nasen- und Ohrenkranke, Klinikum Grosshadern der LMU München.
MMW Fortschr Med. 1999 Oct 7;141(40):28-30, 32, 34.
The number of patients requiring treatment for acute functional disorders of the inner ear has increased over the last decades. The diagnosis sudden loss of hearing is made when the cause of a precipitous hearing impairment cannot be determined with clinical diagnostic means. In the large majority of such cases, the pathogenesis is unclear, with vascular, viral and autoimmune processes most commonly being considered. Against this background, numerous polypragmatic therapeutic measures are employed. In general treatment of sudden loss of hearing employs a combination of several drugs with perfusion-promoting or anti-inflammatory effects. However, the efficacy of such an approach has not been established. The present article discusses a number of known ideas on the pathogenesis of this condition, together with the associated therapeutic strategies, and reports on the importance of nitrogen oxide (NO), which as recent studies appear to show, plays an important role in the physiology of the cochlea.
在过去几十年中，需要治疗内耳急性功能障碍的患者数量有所增加。当无法通过临床诊断手段确定听力急剧下降的原因时，即可诊断为突发性听力损失。在绝大多数此类病例中，发病机制尚不清楚，最常考虑的是血管、病毒和自身免疫过程。在此背景下，人们采用了许多多种用途的治疗措施。一般来说，突发性听力损失的治疗采用几种具有促进灌注或抗炎作用的药物联合使用。然而，这种方法的疗效尚未得到证实。本文讨论了关于这种疾病发病机制的一些已知观点以及相关的治疗策略，并报告了一氧化氮（NO）的重要性，最近的研究似乎表明，一氧化氮在耳蜗生理学中起着重要作用。
