N Engl J Med. 1975 Mar 20;292(12):599-603. doi: 10.1056/NEJM197503202921201.
Two placebo-controlled double-blind studies were initiated to evaluate the therapeutic efficacy of 5-iodo-2-deoxyuridine (idoxuridine) in biopsy-provedcases of herpes simplex virus encephalitis. Twelve patients who on clinical grounds were thought to have herepes simplex virus encephalitis underwent brain biopsy; six of these patients were proved to have this disease, three were considered probable cases,and three were considered doubtful. The patients with proved or probably herpes simplex virus encephalitis were treated with parenteral idoxuridine (or placebo) at a dose of 100 mg per kiogram per day for five days. The occurrence of unacceptable myelosupperssion and the failure of idoxuridine therapy to prevent death led to the premature termination of both studies.
开展了两项安慰剂对照双盲研究，以评估5-碘-2-脱氧尿苷（碘苷）对经活检证实的单纯疱疹病毒性脑炎病例的治疗效果。12名临床上被认为患有单纯疱疹病毒性脑炎的患者接受了脑活检；其中6名患者被证实患有该病，3名被认为很可能患有该病，3名被认为可疑。确诊或很可能患有单纯疱疹病毒性脑炎的患者接受了静脉注射碘苷（或安慰剂）治疗，剂量为每天每千克100毫克，持续5天。由于出现了无法接受的骨髓抑制情况以及碘苷治疗未能预防死亡，两项研究均提前终止。
