BCoR，一种参与BCL-6抑制的新型共抑制因子。
BCoR, a novel corepressor involved in BCL-6 repression.
作者信息
Huynh K D, Fischle W, Verdin E, Bardwell V J
机构信息
Biochemistry, Molecular Biology, and Biophysics Program, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Genes Dev. 2000 Jul 15;14(14):1810-23.
BCL-6 encodes a POZ/zinc finger transcriptional repressor that is required for germinal center formation and may influence apoptosis. Aberrant expression of BCL-6 due to chromosomal translocations is implicated in certain subtypes of non-Hodgkin's lymphoma. The POZ domains of BCL-6 and several other POZ proteins interact with corepressors N-CoR and SMRT. Here we identify and characterize a novel corepressor BCoR (BCL-6 interacting corepressor), which is expressed ubiquitously in human tissues. BCoR can function as a corepressor when tethered to DNA and, when overexpressed, can potentiate BCL-6 repression. Specific class I and II histone deacetylases (HDACs) interact in vivo with BCoR, suggesting that BCoR may functionally link these two classes of HDACs. Strikingly, BCoR interacts selectively with the POZ domain of BCL-6 but not with eight other POZ proteins tested, including PLZF. Additionally, interactions between the BCL-6 POZ domain and SMRT, N-CoR, and BCoR are mutually exclusive. The specificity of the BCL-6/BCoR interaction suggests that BCoR may have a role in BCL-6-associated lymphomas.
BCL-6编码一种POZ/锌指转录抑制因子，它是生发中心形成所必需的，并且可能影响细胞凋亡。由于染色体易位导致的BCL-6异常表达与某些非霍奇金淋巴瘤亚型有关。BCL-6和其他几种POZ蛋白的POZ结构域与共抑制因子N-CoR和SMRT相互作用。在此，我们鉴定并表征了一种新型共抑制因子BCoR（BCL-6相互作用共抑制因子），它在人体组织中普遍表达。当与DNA相连时，BCoR可作为共抑制因子发挥作用，并且在过表达时可增强BCL-6的抑制作用。特定的I类和II类组蛋白去乙酰化酶（HDAC）在体内与BCoR相互作用，这表明BCoR可能在功能上连接这两类HDAC。引人注目的是，BCoR选择性地与BCL-6的POZ结构域相互作用，但不与包括PLZF在内的其他8种测试的POZ蛋白相互作用。此外，BCL-6的POZ结构域与SMRT、N-CoR和BCoR之间的相互作用是相互排斥的。BCL-6/BCoR相互作用的特异性表明BCoR可能在与BCL-6相关的淋巴瘤中发挥作用。
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