Emmerling M R, Watson M D, Raby C A, Spiegel K
Neuroscience Therapeutics, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48106, USA.
Biochim Biophys Acta. 2000 Jul 26;1502(1):158-71. doi: 10.1016/s0925-4439(00)00042-9.
Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer's dementia. This review will examine the origins of complement in the brain and the role of beta-amyloid peptide (Abeta) in complement activation in Alzheimer's disease, an event that might serve as a nidus of chronic inflammation. Pharmacology therapies that may serve to inhibit Abeta-mediated complement activation will also be discussed.
补体蛋白是阿尔茨海默病大脑中淀粉样斑块和脑血管淀粉样蛋白的重要组成部分。它们可在淀粉样蛋白沉积的最早阶段被发现，其激活与阿尔茨海默病痴呆的临床症状同时出现。本综述将探讨大脑中补体的起源以及β-淀粉样肽（Aβ）在阿尔茨海默病补体激活中的作用，这一事件可能是慢性炎症的病灶。还将讨论可能用于抑制Aβ介导的补体激活的药物治疗方法。
