Yamaguchi H, Yamauchi H, Yamada T, Ariyoshi T, Takebayashi S
Department of Cardiovascular Surgery, Oita Prefectural Hospital, 476 Bunyo, Oita 870-8511, Japan.
Ann Thorac Cardiovasc Surg. 2000 Jun;6(3):167-72.
Previous studies on valve replacement in patients over 70 years of age have been concerned with early and long-term outcome. Little is known, however, of the quality of life (QOL) of survivors following surgery.
Thirty-one consecutive patients, mean age 74.0+/-3.1 years, who underwent heart valve replacement were reviewed and questioned as to their physical and social activities before and after surgery and compared with 75 patients aged less than 70 years old who underwent similar procedures during the same time interval. QOL was measured by using the Rosser distress and disability scores.
Hospital mortality in the elderly group was the same as in the younger group (9.7% vs 2.7%, p = 0.121). Median 5-year survival was 79% in the elderly group and 92% in the younger group (p = 0.068). Overall morbidity due to valve-related complications was 3.55%/patient-year in the elderly group and 2. 35%/patient-year in the younger group, and freedom from all valve-related complications at 5 years was 76%, and 83%, respectively (p = 0.202). There were significant improvements in the distress and disability scores postoperatively (mean interval: 32. 4+/-20.4 months). The QOL value rose from 0.960 to 0.981 in the elderly group (p = 0.0004), and from 0.975 to 0.984 in the younger group (p = 0.07), suggesting that the magnitude of improvement in the elderly group was superior to that in the younger group.
Heart valve replacement in patients over the age of 70 years was associated with reasonable early and mid-term morbidity. We believe that significant improvements in the symptoms, functional status, and QOL of the patients can be expected.
先前关于70岁以上患者瓣膜置换的研究关注的是早期和长期结果。然而,对于手术后幸存者的生活质量(QOL)却知之甚少。
对31例连续接受心脏瓣膜置换术的患者进行回顾,这些患者的平均年龄为74.0±3.1岁,并询问他们手术前后的身体和社交活动情况,并与同期75例年龄小于70岁接受类似手术的患者进行比较。采用罗瑟痛苦和残疾评分来衡量生活质量。
老年组的医院死亡率与年轻组相同(9.7%对2.7%,p = 0.121)。老年组5年生存率中位数为79%,年轻组为92%(p = 0.068)。老年组因瓣膜相关并发症导致的总体发病率为3.55%/患者年,年轻组为2.35%/患者年,5年时无所有瓣膜相关并发症的比例分别为76%和83%(p = 0.202)。术后痛苦和残疾评分有显著改善(平均间隔时间:32.4±20.4个月)。老年组的生活质量值从0.960升至0.981(p = 0.0004),年轻组从0.975升至0.984(p = 0.07),这表明老年组的改善幅度优于年轻组。
70岁以上患者的心脏瓣膜置换术与合理的早期和中期发病率相关。我们认为患者的症状、功能状态和生活质量有望得到显著改善。