除WT1、FWT1和FWT2外，家族性肾母细胞瘤易感基因的证据。
Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2.
作者信息
Rapley E A, Barfoot R, Bonaïti-Pellié C, Chompret A, Foulkes W, Perusinghe N, Reeve A, Royer-Pokora B, Schumacher V, Shelling A, Skeen J, de Tourreil S, Weirich A, Pritchard-Jones K, Stratton M R, Rahman N
机构信息
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
出版信息
Br J Cancer. 2000 Jul;83(2):177-83. doi: 10.1054/bjoc.2000.1283.
Abstract
Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found.
摘要
三个基因座与家族性肾母细胞瘤有关
WT1位于11号染色体p13区域，FWT1位于17号染色体q12 - q21区域，FWT2位于19号染色体q13区域。在评估的19个肾母细胞瘤家族中，有两个家族显示出在所有这三个基因座均无连锁的有力证据。这两个家族都至少有三例肾母细胞瘤病例，表明它们极有可能是由遗传易感性引起的，因此仍有待发现一个或多个其他家族性肾母细胞瘤易感基因。
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