设计用于在生理pH值下实现脂质体融合的带有2-硝基苯酚触发基团的脂质类似物。
Lipid analog with 2-nitrophenol trigger designed for liposome fusion at physiological pH.
作者信息
Shah S N, Tomohiro T, Ogawa Y, Kodaka M, Okuno H
机构信息
Biomolecules Department, National Institute of Bioscience and Human-Technology, Tsukuba, Ibaraki, Japan.
出版信息
Lipids. 2000 Jun;35(6):689-91. doi: 10.1007/s11745-000-0574-2.
PMID:10901432
Abstract
A novel lipid analog with two long alkyl (C16) chains, an aspartate skeleton, a connecting alkyl (C8) chain, and 2-nitrophenol trigger group is synthesized by an efficient synthetic route, which can induce liposome fusion at physiological pH.
摘要
通过一种高效合成路线合成了一种新型脂质类似物，其具有两条长烷基（C16）链、一个天冬氨酸骨架、一条连接烷基（C8）链和2-硝基苯酚触发基团，该脂质类似物能够在生理pH值下诱导脂质体融合。
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