Veness M J, Delaney G, Berry M
Department of Radiation Oncology, Liverpool Hospital, New South Wales, Australia.
Australas Radiol. 1999 Aug;43(3):328-33. doi: 10.1046/j.1440-1673.1999.433666.x.
Younger patients (< or = 50 years of age) develop lung cancer. Many series report 5-10% of all cases occurring in younger patients. Outcome, inspite of treatment, is universally poor. Females and adenocarcinomas are over-represented and the aetiology for such an early-age presentation is unclear. The aims of this retrospective study were to review the clinical characteristics, treatment details and outcome of patients aged 50 years or younger diagnosed with lung cancer (small cell and non-small cell). Over a period of 34 months, 497 lung cancer patients were treated at the Liverpool Hospital Cancer Therapy Centre. Thirty-seven (7.4%) patients aged less than or equal to 50 years were identified. The median age at diagnosis was 44 years (range 32-49 years) in 20 females and 17 males. Adenocarcinoma was the predominant histological subtype (32%). No referred patient had stage I/II disease. Almost 90% of patients were smokers. Median survival following diagnosis was 12 months (range, 9 days-68 months) with 70% having died by the close of study. The clinical characteristics and outcome of young patients in our study were comparable to other similar series.
年轻患者（≤50岁）会患肺癌。许多系列报道称，所有病例中有5% - 10%发生在年轻患者中。尽管接受了治疗，但总体预后较差。女性和腺癌的比例过高，而这种早期发病的病因尚不清楚。这项回顾性研究的目的是回顾50岁及以下被诊断为肺癌（小细胞癌和非小细胞癌）患者的临床特征、治疗细节及预后。在34个月的时间里，利物浦医院癌症治疗中心共治疗了497例肺癌患者。其中37例（7.4%）患者年龄小于或等于50岁。20名女性和17名男性的诊断时中位年龄为44岁（范围32 - 49岁）。腺癌是主要的组织学亚型（32%）。没有转诊患者处于I/II期疾病。几乎90%的患者是吸烟者。诊断后的中位生存期为12个月（范围9天 - 68个月），到研究结束时70%的患者已经死亡。我们研究中年轻患者的临床特征和预后与其他类似系列研究相当。
