Hogan G R
Department of Biology, Austin Peay State University, Clarksville, TN 37044, USA.
Sci Total Environ. 2000 Jul 10;256(2-3):185-9. doi: 10.1016/s0048-9697(00)00486-1.
The biotoxic effects of vanadium are variable depending upon a number of factors including the oxidation state of the test compound. This study reports the effects of three vanadium compounds on peripheral erythrocytes. On day 0 female ICR mice received a single injection of vanadium chloride (V-III), vanadyl sulfate (V-IV), or sodium orthovandate (V-V). At scheduled intervals post-injection, the number of circulating erythrocytes [red blood cells per millimeter cubed (RBC/mm3)], reticulocyte percentages, and radioiron uptake percentages were determined and compared to mice receiving saline only. Data show that all three test substances promoted a significant lowering of RBC/mm3 beginning on day 1 for V-IV and V-V and on day 2 for V-III through day 4. The reticulocyte percentages increase followed the same time course as that of the peripheral RBC decrease. Peak reticulocytosis was noted on days 2 and 4 for all three vanadium-treated groups; for V-IV and V-V the increase continued to day 6. Radioiron data showed an erythropoietic stimulation by a significant increase in uptake percentages on days 4-6 after vanadium injections compared to saline-treated controls.
钒的生物毒性效应因多种因素而异，包括受试化合物的氧化态。本研究报告了三种钒化合物对外周红细胞的影响。在第0天，雌性ICR小鼠单次注射氯化钒（V-III）、硫酸氧钒（V-IV）或原钒酸钠（V-V）。在注射后的预定时间间隔，测定循环红细胞数量[每立方毫米红细胞数（RBC/mm³）]、网织红细胞百分比和放射性铁摄取百分比，并与仅接受生理盐水的小鼠进行比较。数据显示，所有三种受试物质均导致RBC/mm³显著降低，V-IV和V-V从第1天开始，V-III从第2天开始至第4天。网织红细胞百分比的增加与外周红细胞减少的时间进程相同。所有三个钒处理组在第2天和第4天出现网织红细胞增多峰值；对于V-IV和V-V，增加持续到第6天。放射性铁数据显示，与生理盐水处理的对照组相比，钒注射后第4至6天摄取百分比显著增加，表明有促红细胞生成作用。
