Alberti C, Tironi C, Deleide G
Farmaco Sci. 1975 Jan;30(1):20-34.
A report is given of the variations in bacteriostatic activity on introduction of a hydrophilic group, the hydroxyl group (-OH), at positions 2',3' and 4' of the phenyl group linked to the heterocyclic nitrogen os 1-phenyl-5-sulfanilamidopyrazole (I: R = -H) and of 1-phenyl-3-methyl-5-sulfanilamidopyrazole (II: R = -H). The substances prepared for this purpose: 1-(hydroxyphenyl)-5-sulfanilamidopyrazoles (Ia)(Ib))(Ic)(-OH at 2', 3',4') and 1-(hydroxyphenyl)-3-methyl-5-sulfanilamidopyrazoles (IIa)(IIb)(IIc)(-OH at 2',3'4') in vitro tests of bacteriostatic activity against strains of S. aureus and E. coli gave the following results: See journal for results.
报告了在与杂环氮相连的苯基的2'、3'和4'位引入亲水性基团羟基（-OH）对1-苯基-5-磺胺基吡唑（I：R = -H）和1-苯基-3-甲基-5-磺胺基吡唑（II：R = -H）抑菌活性的影响。为此制备的物质：1-（羟基苯基）-5-磺胺基吡唑（Ia）（Ib）（Ic）（2'、3'、4'位有-OH）和1-（羟基苯基）-3-甲基-5-磺胺基吡唑（IIa）（IIb）（IIc）（2'、3'、4'位有-OH）对金黄色葡萄球菌和大肠杆菌菌株的体外抑菌活性测试结果如下：结果见期刊。
