Calleri L F, Taccani C, Porcelli A
Cattedra di Clinica Ostetrica e Ginecologica, Facolta di Medicina e Chirurgia, Novara, Università degli Studi, Torino.
Minerva Ginecol. 2000 Mar;52(3):49-58.
The aim of this study was to evaluate a correlation between PROM and genital infections.
A total of 308 vaginal swabs were made in randomized study group composed by 184 pregnant women aged between 26 and 32 years with an extreme age of 19 (one) and 40 years (one). Three vaginal swabs and one cervical swab (searching for Chlamydia) were made for every patient. Sixteen patients were excluded during this study, because they decided to have their babies in other hospitals. Therefore, the patients totally included in the study were 166: 109 at the first pregnancy, 33 at the second pregnancy and 5 at the third pregnancy. No one of them had any spontaneous abortion in the past. All possible other factor which ca be considered responsible and/or inductive of premature ruptures, such as cervical incontinence, cigarette smoke and coitus were excluded.
280 vaginal swabs were made in this study: 134 were positive, with a global positivity percentage of 47.85%. Premature rupture of membranes (PROM) was observed in 38 cases with an incidence of 23.03%: 26 were PROM and 12 were pPROM. The extreme pPROMs occurred, respectively, at the 21st and at 34th gestational week; 29 of the 38 cases of PROM, were associated with positive cultures. The results obtained show an evident correlation between PROM and Ureaplasma urealyticum vaginosis: this fact is improved by the high incidence percentage of this mycobacter in pregnant women and also by an absolute predomination of Ureplasma urealyticum in PROM cases (72.41%).
These data obtained confirm the importance of this microorganism in PROM genesis, according to some recent studies. It is suggested that Ureaplasma urealyticum infection can contribute to a premature start of labour.
本研究旨在评估胎膜早破（PROM）与生殖道感染之间的相关性。
在一个随机研究组中，对184名年龄在26至32岁之间的孕妇进行了总共308次阴道拭子采样，年龄极值为19岁（1例）和40岁（1例）。为每位患者采集了三次阴道拭子和一次宫颈拭子（用于检测衣原体）。在本研究期间，有16名患者被排除，因为他们决定在其他医院分娩。因此，纳入本研究的患者共有166名：初产妇109名，经产妇33名，三产妇5名。她们既往均无自然流产史。所有可能被认为与胎膜早破相关和/或诱发胎膜早破的其他因素，如宫颈机能不全、吸烟和性交等均被排除。
本研究共采集了280次阴道拭子：134次呈阳性，总体阳性率为47.85%。观察到38例胎膜早破，发生率为23.03%：26例为足月前胎膜早破（PROM），12例为未足月胎膜早破（pPROM）。最早的未足月胎膜早破分别发生在妊娠第21周和第34周；38例胎膜早破病例中有29例与培养阳性相关。所得结果显示胎膜早破与解脲脲原体性阴道炎之间存在明显相关性：孕妇中该支原体的高发病率以及胎膜早破病例中解脲脲原体的绝对优势（72.41%）进一步证明了这一事实。
根据最近的一些研究，所获得的这些数据证实了这种微生物在胎膜早破发生中的重要性。提示解脲脲原体感染可能促使分娩过早开始。
