一种新型呼吸道合胞病毒特异性人细胞毒性T淋巴细胞表位的鉴定
Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
作者信息
Goulder P J, Lechner F, Klenerman P, McIntosh K, Walker B D
机构信息
Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
出版信息
J Virol. 2000 Aug;74(16):7694-7. doi: 10.1128/jvi.74.16.7694-7697.2000.
Abstract
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells.
摘要
呼吸道合胞病毒（RSV）感染是全球儿童发病的主要原因。本文描述了首个被确定的人类RSV特异性细胞毒性T淋巴细胞表位。利用B7-RSV-NP四聚体复合物对CD8(+) T细胞进行染色，在4名健康的、B7阳性的成年受试者中检测到核蛋白（NP）中这个受HLA B7限制的表位。
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