呼吸道合胞病毒融合蛋白的HLA I类限制性细胞毒性T细胞表位
HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein.
作者信息
Brandenburg A H, de Waal L, Timmerman H H, Hoogerhout P, de Swart R L, Osterhaus A D
机构信息
Institute of Virology, Erasmus University Hospital, 3000 DR Rotterdam, The Netherlands.
出版信息
J Virol. 2000 Nov;74(21):10240-4. doi: 10.1128/jvi.74.21.10240-10244.2000.
Abstract
Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.
摘要
病毒特异性细胞毒性T淋巴细胞（CTL）在清除呼吸道合胞病毒（RSV）感染中起主要作用。我们从两名刚从严重RSV感染中康复的婴儿体内获得了细胞毒性T细胞克隆（TCC）。对这些TCC进行了功能特性分析，并用于鉴定RSV的HLA I类（B57和C12）限制性CTL表位。
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