Büyük A Y, Kavala M
Division of Dermatology, SSK Göztepe Educational Hospital, IStanbul, Turkey.
J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):260-2. doi: 10.1067/mjd.2000.104683.
Oral metronidazole has been reported to be effective in some patients with idiopathic lichen planus (LP) who did not have concomitant protozoal infections of the intestinal or genital tracts.
Our purpose was to evaluate the efficacy of this drug in the treatment of generalized LP.
Nineteen patients with LP who were free from intestinal and genital protozoal infections were treated with oral metronidazole, 500 mg twice daily, for 20 to 60 days and were followed up for a period of 5 to 36 months.
Fifteen patients (78.9%) improved with metronidazole treatment. Complete response was observed in 13 patients (7 women and 6 men). Two patients responded partially. Worsening of the lesions was observed in 1 of the 4 nonresponding patients.
Metronidazole may be an alternative therapy for the treatment of generalized LP. Its immunomodulatory activity seems to be a possible mechanism of action besides its antimicrobial activity.
据报道，口服甲硝唑对一些无肠道或生殖道原虫感染的特发性扁平苔藓（LP）患者有效。
我们的目的是评估该药治疗泛发性LP的疗效。
19例无肠道和生殖道原虫感染的LP患者接受口服甲硝唑治疗，每日2次，每次500mg，疗程20至60天，并随访5至36个月。
15例患者（78.9%）经甲硝唑治疗后病情改善。13例患者（7名女性和6名男性）完全缓解。2例患者部分缓解。4例无反应患者中有1例病情恶化。
甲硝唑可能是治疗泛发性LP的一种替代疗法。除抗菌活性外，其免疫调节活性似乎是一种可能的作用机制。
