替硝唑含漱液治疗口腔扁平苔藓：一项观察性初步研究。

Tinidazole mouth rinse for the treatment of oral lichen planus: an observational pilot study.

机构信息

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, China.

出版信息

BMC Oral Health. 2024 Sep 27;24(1):1145. doi: 10.1186/s12903-024-04881-8.

DOI:10.1186/s12903-024-04881-8

PMID:39334232

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438045/

Abstract

BACKGROUND

Given the limited treatment options available for oral lichen planus (OLP), a study was undertaken to obtain preliminary information on the therapeutic efficacy of tinidazole mouth rinse in patients with OLP.

METHODS

A prospective, open-label pilot study was conducted to assess the efficacy of thrice-daily tinidazole mouth rinse for one week in OLP patients (n = 27). Reticulation/erythema/ulceration (REU) scores and visual analog scale (VAS) scores were used to measure lesions at baseline and after one week of treatment. Mucosal samples were collected, and the abundance of Fusobacterium nucleatum was quantified using RT-PCR. Statistical analysis using t-test, Wilcoxon signed rank test and Pearson correlation test.

RESULTS

After treatment, VAS scores significantly decreased in both reticular (P = 0.03) and erosive OLP patients (P = 0.003). However, REU scores significantly decreased only in erosive OLP patients (P = 0.002). The relative abundance of Fusobacterium nucleatum on the damaged mucosa surface significantly decreased in all OLP patients (P = 0.01). In erosive OLP patients, the triamcinolone group showed a significantly greater improvement in VAS scores compared to the tinidazole group (P = 0.01). However, there was no statistically significant correlation between the relative abundance of Fusobacterium nucleatum and REU scores in OLP patients (r = 0.0754, P = 0.61).

CONCLUSION

Tinidazole mouth rinse showed potential in reducing disease severity in OLP patients and was well-tolerated, suggesting its viability as a local therapeutic option. However, randomized controlled studies are warranted to confirm these preliminary findings.

摘要

背景

鉴于口腔扁平苔藓（OLP）的治疗选择有限，进行了一项研究，以获得替硝唑漱口液治疗 OLP 患者的疗效初步信息。

方法

进行了一项前瞻性、开放标签的初步研究，以评估替硝唑漱口液每日三次漱口一周治疗 OLP 患者（n=27）的疗效。使用网状/红斑/溃疡（REU）评分和视觉模拟评分（VAS）在基线和治疗一周后评估病变。收集黏膜样本，并使用 RT-PCR 定量检测福赛斯坦纳菌的丰度。使用 t 检验、Wilcoxon 符号秩检验和 Pearson 相关检验进行统计分析。

结果

治疗后，网状和糜烂性 OLP 患者的 VAS 评分均显著降低（P=0.03 和 P=0.003）。然而，仅在糜烂性 OLP 患者中，REU 评分显著降低（P=0.002）。所有 OLP 患者受损黏膜表面的福赛斯坦纳菌相对丰度均显著降低（P=0.01）。在糜烂性 OLP 患者中，与替硝唑组相比，曲安奈德组的 VAS 评分改善更显著（P=0.01）。然而，福赛斯坦纳菌的相对丰度与 OLP 患者的 REU 评分之间无统计学相关性（r=0.0754，P=0.61）。