Chlebna-Sokół D, Jakubowska E, Sikora A
Klinika Propedeutyki Pediatrii Instytutu Pediatrii Akademii Medycznej w Lodzi.
Przegl Lek. 2000;57(2):83-6.
The aim of the study was to evaluate the occurrence of clinical and biochemical symptoms of osteoporosis in 15 children aged from 10 to 18 years. In this group were 7 children with idiopathic juvenile osteoporosis, 2--with osteogenesis imperfecta and 6 children with secondary osteoporosis. The diagnosis of osteoporosis was based on the result of densitometric examination. The examination was performed with dual-energy X-ray absor-ptiometry (DEXA), with modality by Lunar. Anamnesis and clinical symptoms supported by X-ray examination of the painful region were used as a standard procedure. Biochemical examinations of calcium-phosphorus metabolism included ions and PTH concentrations in blood serum, and the activity of bone isoenzyme of AP. Besides, ions excretion and total hydroxyproline in 24 hrs collection of urine were assessed. The results of our investigations showed that in children with osteoporosis clinical and biochemical abnormalities were various. Pain in the lower limbs and weakening of muscle strength were the most frequently observed clinical symptoms. Among biochemical indices, urine excretion of hydroxyproline and increased concentration of isoenzyme of alkaline phosphatase were of the greatest practical significance.
本研究的目的是评估15名年龄在10至18岁儿童中骨质疏松症的临床和生化症状的发生情况。该组中有7名患有特发性青少年骨质疏松症的儿童，2名患有成骨不全症的儿童和6名患有继发性骨质疏松症的儿童。骨质疏松症的诊断基于骨密度检查结果。检查采用双能X线吸收法（DEXA），使用Lunar设备进行。以病史和疼痛部位的X线检查所支持的临床症状作为标准程序。钙磷代谢的生化检查包括血清中的离子和甲状旁腺激素浓度，以及碱性磷酸酶骨同工酶的活性。此外，还评估了24小时尿液收集物中的离子排泄和总羟脯氨酸。我们的调查结果表明，骨质疏松症儿童的临床和生化异常情况各不相同。下肢疼痛和肌肉力量减弱是最常观察到的临床症状。在生化指标中，羟脯氨酸的尿排泄和碱性磷酸酶同工酶浓度升高具有最大的实际意义。
