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[An experimental study of the role of a blockade of serotonin 5-HT3 receptors and dopamine D2 receptors in the mechanism of the occurrence of early radiation vomiting in monkeys].

作者信息

Martirosov K S, Grigor'ev Iu G, Zorin V V, Andrianova I E

机构信息

State Research Center of Russia, Institute of Biophysics, Moscow.

出版信息

Radiats Biol Radioecol. 2000 May-Jun;40(3):277-80.

PMID:10907404
Abstract

The experiments with M. fasciculata monkeys exposed to 137Cs gamma-radiation with a dose of 6.9 Gy showed that Latranum, a blocker of serotonin 5-HT3 receptors, is a more efficient antiemetic than Dimetphramidum, a D2 dophamin lytic. This is suggested by fewer animals with emetic reaction of by less severe vomiting in case they have any. The results agree well with a hypothesis that serotonin receptors are dominant in the chemoreceptor trigger zone of monkeys.

摘要

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