5-羟色胺3拮抗剂受体：它们在药物性呕吐中的作用。
5HT3-antagonist receptors: their role in drug-induced emesis.
作者信息
Dieras V, Extra J M, Le Bonniec M, Madelaine I, Espie M, Marty M
机构信息
Service de Médecine Oncologique, Paris, France.
出版信息
Nouv Rev Fr Hematol (1978). 1990;32(6):449-52.
PMID:1983228
Abstract
Chemotherapy-induced emesis is the most severe side effect in term of patient's perception. Current anti-emetic regimen as high dose metoclopramide can achieve a complete response in less than 60% of patients. The HT3 receptors appear to be the principal mediator of the emetic effect and their blockade have a clear activity in the prevention of acute drug-induced emesis, superior to reference regimens.
摘要
化疗引起的呕吐是患者感知中最严重的副作用。目前的止吐方案，如高剂量甲氧氯普胺，在不到60%的患者中能实现完全缓解。5-羟色胺3（HT3）受体似乎是呕吐效应的主要介质，阻断这些受体在预防急性药物性呕吐方面具有明显活性，优于参考方案。
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