Shiga Y, Onodera H, Shimizu H, Kimura I, Ohnuma A, Itoyama Y
Department of Neurology, Tohoku University School of Medicine, Japan.
Electromyogr Clin Neurophysiol. 2000 Jun;40(4):237-41.
To electrophysiologically diagnose amyotrophic lateral sclerosis (ALS), fasciculation potentials (FPs) were evaluated in each wasted muscle in 12 ALS and 14 other neurogenic disorders (non-ALS patients). Various types of FPs were observed in ALS. The number of discharged FPs and firing rate of FPs were significantly increased in ALS compared to those in non-ALS. These findings indicate that more motor units take part in discharging FPs in ALS than in non-ALS, and that injured lower motor neurons exhibit hyperexcitability. Although nine of 12 ALS patients showed two consecutive FPs having different motor unit origins, non-ALS patients did not show such FPs. Since the two consecutive FPs having different motor unit origins reflect an involvement of both upper and lower motor neurons, these potentials are an electrophysiologically pathognomonic finding to ALS.
为了通过电生理诊断肌萎缩侧索硬化症（ALS），我们在12例ALS患者和14例其他神经源性疾病患者（非ALS患者）的每块萎缩肌肉中评估了肌束震颤电位（FPs）。在ALS患者中观察到了各种类型的FPs。与非ALS患者相比，ALS患者中FPs的放电数量和放电频率显著增加。这些发现表明，与非ALS患者相比，更多的运动单位参与了ALS患者中FPs的放电，并且受损的下运动神经元表现出兴奋性增高。尽管12例ALS患者中有9例显示出两个连续的具有不同运动单位起源的FPs，但非ALS患者未显示出此类FPs。由于两个连续的具有不同运动单位起源的FPs反映了上、下运动神经元均受累，因此这些电位是ALS的电生理特征性表现。
