Drost Gea, Kleine Bert U, Stegeman Dick F, van Engelen Baziel G M, Zwarts Machiel J
Institute of Neurology, Department of Clinical Neurophysiology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.
J Clin Neurophysiol. 2007 Jun;24(3):301-7. doi: 10.1097/WNP.0b013e31803bba04.
Fasciculation potentials (FPs) are observed in healthy individuals, but also in patients with neurogenic disorders. The exact site of origin and the clinical relevance in distinguishing, for example, amyotrophic lateral sclerosis (ALS) from other neurogenic diseases based on specific characteristics of the FPs is still a matter of debate and needs further exploration. This report describes the use of high-density surface EMG (HD-sEMG), with multiple electrodes in a compact grid to noninvasively record FPs. The technique provides both temporal and spatial information of fasciculations. Examples of the FPs of a patient diagnosed with definite ALS are presented. FPs are shown in different electrode montages and the unique spatial characteristics of different FPs are presented. During 30-second recordings, 137 FPs were detected that via a decomposition algorithm could be assigned to 11 different underlying sources. It is concluded that HD-sEMG, both because of its noninvasive character and the unique spatiotemporal information, is very suitable to examine fasciculations. It allows long stable recording times and provides quantitative information. This electrophysiologic tool is expected to expand the existing knowledge of FP properties.
束颤电位（FPs）在健康个体中可见，在神经源性疾病患者中也可观察到。束颤电位的确切起源部位以及基于其特定特征在区分例如肌萎缩侧索硬化症（ALS）与其他神经源性疾病方面的临床相关性仍存在争议，需要进一步探索。本报告描述了使用高密度表面肌电图（HD-sEMG），通过紧凑网格中的多个电极来无创记录束颤电位。该技术可提供束颤的时间和空间信息。展示了一名被诊断为明确ALS患者的束颤电位实例。呈现了不同电极组合下的束颤电位以及不同束颤电位独特的空间特征。在30秒的记录过程中，检测到137个束颤电位，通过分解算法可将其归为11个不同的潜在来源。得出的结论是，HD-sEMG因其无创性以及独特的时空信息，非常适合用于检查束颤。它允许长时间稳定记录，并提供定量信息。这种电生理工具有望扩展对束颤电位特性的现有认识。
