Mutoh T, Kanamaru A, Kojima K, Nishimura R, Sasaki N, Tsubone H
Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
J Vet Med Sci. 2000 Jun;62(6):665-8. doi: 10.1292/jvms.62.665.
The aim of this study was to determine the effect of perineural capsaicin (CAPS) treatment on cardiopulmonary reflexes elicited by topical laryngeal instillation of CAPS and distilled water (DW) in sevoflurane-anesthetized dogs. Cardiopulmonary reflexes elicited by CAPS (10 microg/ml, 10 ml) were attenuated by perineural CAPS treatment to the superior laryngeal nerves (SLNs) (P<0.05), whereas those by DW (10 ml) remained unaffected (P>0.05). The reflex responses to DW that remained even after the perineural CAPS treatment were eliminated by laryngeal anesthesia with lidocaine. These results suggest that cardiopulmonary reflexes from the laryngeal mucosa elicited by CAPS instillation can be blocked by perineural CAPS treatment to the SLNs, which may result from inhibition of the laryngeal CAPS-sensitive C-fiber afferents.
本研究的目的是确定在七氟醚麻醉的犬中，经神经周围给予辣椒素（CAPS）处理对经喉局部滴注CAPS和蒸馏水（DW）所引发的心肺反射的影响。经神经周围给予CAPS处理喉上神经（SLNs）后，由CAPS（10微克/毫升，10毫升）引发的心肺反射减弱（P<0.05），而由DW（10毫升）引发的心肺反射未受影响（P>0.05）。经神经周围给予CAPS处理后仍存在的对DW的反射反应，可通过利多卡因喉麻消除。这些结果表明，经神经周围给予CAPS处理SLNs可阻断由滴注CAPS引发的来自喉黏膜的心肺反射，这可能是由于抑制了喉内对CAPS敏感的C纤维传入神经所致。
