Mutoh T, Tsubone H, Nishimura R, Sasaki N
Division of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Respir Physiol. 1998 Jun;112(3):253-64. doi: 10.1016/s0034-5687(98)00028-0.
Effects of halothane, enflurane, isoflurane, and sevoflurane on vagal capsaicin (CAPS)-sensitive C-fibers were elucidated in anesthetized dogs. The CAPS-sensitive C-fibers were significantly stimulated by all volatile anesthetics with a significantly greater response to halothane than with sevoflurane. A significant increase in respiratory frequency (fR) and a significant decrease in tidal volume (VT) were observed with halothane and isoflurane, and a significant increase in fR was observed with sevoflurane. In contrast, a significant decrease in fR was induced by enflurane. The tachypnea induced by halothane, isoflurane, and sevoflurane was significantly reduced or no longer observed after perineural CAPS-treatment or bilateral vagotomy, whereas the slowing of respiration observed with enflurane was not affected by either of these treatments. These results suggest that vagal C-fibers play an important role in the reflex tachypnea that occurs with halothane, isoflurane, and sevoflurane.
在麻醉犬中阐明了氟烷、恩氟烷、异氟烷和七氟烷对迷走神经辣椒素（CAPS）敏感的C纤维的影响。所有挥发性麻醉剂均能显著刺激CAPS敏感的C纤维，其中氟烷引起的反应显著大于七氟烷。使用氟烷和异氟烷时观察到呼吸频率（fR）显著增加，潮气量（VT）显著降低，使用七氟烷时观察到fR显著增加。相比之下，恩氟烷可导致fR显著降低。在神经周围给予CAPS治疗或双侧迷走神经切断术后，氟烷、异氟烷和七氟烷引起的呼吸急促显著减轻或不再出现，而恩氟烷引起的呼吸减慢不受这两种治疗的影响。这些结果表明，迷走神经C纤维在氟烷、异氟烷和七氟烷引起的反射性呼吸急促中起重要作用。
