Angeby K A, Alvarado-Gálvez C, Pineda-García L, Hoffner S E
Swedish Institute for Infectious Disease Control, Solna.
Int J Tuberc Lung Dis. 2000 Jul;4(7):684-7.
Diagnosis of tuberculosis in low-income countries is hindered by the low sensitivity of direct sputum smear microscopy. We compared an improved method based on liquefaction of sputum with NaOCl followed by centrifugation with standard direct smear in a central hospital and at peripheral health centres in Honduras. Specificity was high and sensitivity significantly better with the NaOCl method. Moreover, this technique is safe, inexpensive and easy to perform. We recommend its implementation to enable rapid, sensitive laboratory diagnosis of pulmonary tuberculosis, especially in resource-poor settings where culture is not possible.
在低收入国家，直接痰涂片显微镜检查的低敏感性阻碍了结核病的诊断。我们在洪都拉斯的一家中心医院和周边卫生中心，将一种基于用次氯酸钠液化痰液然后离心的改进方法与标准直接涂片法进行了比较。次氯酸钠法的特异性很高，敏感性也明显更好。此外，这项技术安全、廉价且易于操作。我们建议采用该方法，以便能够对肺结核进行快速、灵敏的实验室诊断，尤其是在无法进行培养的资源匮乏地区。
