Selvaggi S M, Guidos B J
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Diagn Cytopathol. 2000 Jul;23(1):23-6. doi: 10.1002/1097-0339(200007)23:1<23::AID-DC5>3.0.CO;2-K.
The ThinPrep Pap Test (Cyryc Corp., Boxborough, MA) has proven to be effective in decreasing the number of cervical specimens limited for interpretation by blood/inflammatory exudate as compared to conventional smears. However, its effectiveness in decreasing the number of preparations which lack an endocervical component is less well-established. The purpose of this 1-yr study (January 1998-December 1998) was to determine if the collecting instruments used by physicians played a role in the lack of an endocervical component on ThinPrep slides. On implementation of the ThinPrep Pap Test for cervical cytology, the broom-type sampling device (Papette, Wallach Surgical Devices, Inc., Millford, CT) was the FDA-approved collecting instrument. Subsequently the combined plastic spatula/Zelsmyr Cytobrush (Medscand, Inc., Hollywood, FL) were approved. A survey was sent to 102 physicians in seven primarY care sites and two private obstetrics-gynecology practices affiliated with the Loyola University Health Care System. One site used the broom only, one site used the spatula/cytobrush, five sites used the broom/cytobrush, and in two sites, two different sets of collecting instruments were utilized. Of the 10,241 ThinPrep samples, 620 (6%) were obtained with the broom only, 432 (4.3%) with the spatula/cytobrush, and 9,189 (89.7%) with the broom/cytobrush. An endocervical component was absent in 24% (range, 13.7-25%) of the cervical samples collected with the broom only, 10% (range, 8.4-12.5%) with the spatula/cytobrush, and 13% (range, 6.2-18.8%) with the broom/ cytobrush. The spatula/cytobrush and the broom/cytobrush showed statistical significance (P < 0.001) over the broom alone in the collection of an endocervical component. The results of this study indicate that the collecting instruments used by the physician(s) played a role in the adequacy (endocervical component) of the specimen processed by the ThinPrep method. Diagn. Cyto
与传统涂片相比，ThinPrep巴氏试验（Cyryc公司，马萨诸塞州博克斯伯勒）已被证明能有效减少因血液/炎性渗出物导致难以判读的宫颈标本数量。然而，其在减少缺乏宫颈管成分的制片数量方面的有效性尚缺乏充分证据。这项为期1年（1998年1月至1998年12月）的研究旨在确定医生使用的采集器械是否与ThinPrep玻片上缺乏宫颈管成分有关。在将ThinPrep巴氏试验用于宫颈细胞学检查时，扫帚型采样装置（Papette，Wallach外科器械公司，康涅狄格州米尔福德）是经美国食品药品监督管理局（FDA）批准的采集器械。随后，塑料刮板/Zelsmyr细胞刷组合（Medscand公司，佛罗里达州好莱坞）也获得批准。向洛约拉大学医疗系统下属的7个初级保健机构和2个私立妇产科诊所的102名医生发送了一份调查问卷。其中一个机构仅使用扫帚，一个机构使用刮板/细胞刷，5个机构使用扫帚/细胞刷，还有2个机构使用两组不同的采集器械。在10241份ThinPrep样本中，仅用扫帚采集的有620份（6%），用刮板/细胞刷采集的有432份（4.3%），用扫帚/细胞刷采集的有9189份（89.7%）。仅用扫帚采集的宫颈样本中，24%（范围为13.7% - 25%）缺乏宫颈管成分；用刮板/细胞刷采集的样本中，这一比例为10%（范围为8.4% - 12.5%）；用扫帚/细胞刷采集的样本中，这一比例为13%（范围为6.2% - 18.8%）。在采集宫颈管成分方面，刮板/细胞刷和扫帚/细胞刷与仅用扫帚相比具有统计学意义（P < 0.001）。这项研究结果表明，医生使用的采集器械对ThinPrep方法处理的标本的充分性（宫颈管成分）有影响。诊断细胞病理学
