Takashima S, Takayama F, Saito A, Wang Q, Hidaka K, Sone S
Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan.
Thyroid. 2000 Jun;10(6):507-10. doi: 10.1089/thy.2000.10.507.
We present a case of primary thyroid lymphoma coexisting with Hashimoto's thyroiditis in a 75-year-old woman in whom B-cell lymphoma was substantiated based on the findings of immunophenotyping and polymerase chain reaction (PCR) gene rearrangement in specimens that had been obtained by ultrasound (US)-guided fine-needle aspiration biopsy (FNAB). The immunophenotyping technique showed A light chain restriction, and PCR-based assays showed a discrete narrow band, which was diagnostic for clonal B-cell proliferation. Analyses of PCR gene rearrangement in US-guided FNAB may be a useful ancillary technique to pathological findings for diagnosis of primary thyroid lymphoma, especially for differentiation between low-grade B-cell lymphomas and Hashimoto's thyroiditis.
我们报告了一例75岁女性原发性甲状腺淋巴瘤合并桥本甲状腺炎的病例。通过超声（US）引导下细针穿刺活检（FNAB）获取的标本，经免疫表型分析和聚合酶链反应（PCR）基因重排检测，证实为B细胞淋巴瘤。免疫表型分析技术显示轻链限制，基于PCR的检测显示出一条离散的窄带，这是克隆性B细胞增殖的诊断依据。超声引导下FNAB的PCR基因重排分析可能是一种有助于原发性甲状腺淋巴瘤诊断的辅助技术，特别是用于区分低度B细胞淋巴瘤和桥本甲状腺炎。
