Pittler M H, Vogler B K, Ernst E
Department of Complementary Medicine, School of Postgraduate Medicine & Health Sciences, University of Exeter, United Kingdom, 25 Victoria Park Road, Exeter, Devon, UK, EX2 4NT.
Cochrane Database Syst Rev. 2000(3):CD002286. doi: 10.1002/14651858.CD002286.
Feverfew (Tanacetum parthenium L.) is a popular herbal remedy for migraine.
To systematically review the evidence for or against the efficacy of feverfew versus placebo for the prevention of migraine.
Electronic literature searches were performed using the databases CISCOM (Research Council for Complementary Medicine, London, UK), MEDLINE, EMBASE, Biosis and the Cochrane Library (each from its inception to April 1998). Manufacturers were contacted and the bibliographies of identified articles checked for further trials.
Randomised, placebo-controlled, double-blind trials assessing the efficacy of feverfew for preventing migraine were included. No restrictions regarding the language of publication were imposed.
Data on patients, interventions, methods, outcomes and results were extracted in a pre-defined, standardised manner. Methodological quality was evaluated using the scoring system developed by Jadad and colleagues. Both data extraction and the assessment of methodological quality were performed independently by two reviewers.
Four trials met the inclusion criteria. The majority of these trials suggested beneficial effects of feverfew compared with placebo. However, the trial with the highest methodological quality, which was also among the largest, found no significant difference between feverfew and placebo.
REVIEWER'S CONCLUSIONS: The efficacy of feverfew for the prevention of migraine has not been established beyond reasonable doubt.
小白菊（Tanacetum parthenium L.）是一种常用的治疗偏头痛的草药。
系统评价小白菊与安慰剂相比预防偏头痛疗效的证据。
使用CISCOM（英国伦敦补充医学研究委员会）、MEDLINE、EMBASE、Biosis和Cochrane图书馆（均从创刊至1998年4月）数据库进行电子文献检索。联系了制造商，并检查了已识别文章的参考文献以寻找进一步的试验。
纳入评估小白菊预防偏头痛疗效的随机、安慰剂对照、双盲试验。对发表语言没有限制。
以预先定义的标准化方式提取有关患者、干预措施、方法、结局和结果的数据。使用Jadad及其同事开发的评分系统评估方法学质量。数据提取和方法学质量评估均由两名评价者独立进行。
四项试验符合纳入标准。这些试验中的大多数表明与安慰剂相比小白菊有有益作用。然而，方法学质量最高且也是规模最大的试验之一，发现小白菊与安慰剂之间没有显著差异。
小白菊预防偏头痛的疗效尚未得到确凿证实。
