Hou Y C, Hsiu S L, Yen H F, Chen C C, Chao P D
Graduate Institute of Chinese Pharmaceutical Sciences, Taichung, Taiwan, R.O.C.
Planta Med. 2000 Jun;66(5):439-43. doi: 10.1055/s-2000-8582.
To measure naringin/naringenin absorption of a decoction prepared from the pericarps of Citrus grandis and to investigate the effect of honey on naringin/naringenin absorption, six healthy males received 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis in a randomized crossover design. The absorption was measured by renal recovery of naringenin glucuronides/sulfates over 48 hours. The contents of naringin/naringenin in 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis were determined to be 261.5/23.8 mumol and 303.3/11.6 mumol, respectively. The mean cumulated renal excretion of naringenin glucuronides/sulfates after intake of these two decoctions were 74.8 mumol (26.2% of dose) and 49.8 mumol (15.8% of dose), respectively. Paired Student's t-test showed that the difference of the total renal recovery of naringin/naringenin between the two decoctions was significant. The results indicated that honey significantly reduced naringin/naringenin absorption by 33.4% in humans and suggested that honey treatment might alter the efficacy of Pericarpium Citri Grandis.
为测定由柚皮制备的汤剂中柚皮苷/柚皮素的吸收情况，并研究蜂蜜对柚皮苷/柚皮素吸收的影响，6名健康男性采用随机交叉设计，分别服用200 mL未处理和经蜂蜜处理的柚皮汤剂。通过48小时内柚皮素葡萄糖醛酸苷/硫酸盐的肾脏回收率来测定吸收情况。未处理和经蜂蜜处理的柚皮200 mL汤剂中柚皮苷/柚皮素的含量分别测定为261.5/23.8 μmol和303.3/11.6 μmol。服用这两种汤剂后，柚皮素葡萄糖醛酸苷/硫酸盐的平均累积肾脏排泄量分别为74.8 μmol（占剂量的26.2%）和49.8 μmol（占剂量的15.8%）。配对学生t检验显示，两种汤剂之间柚皮苷/柚皮素的总肾脏回收率差异显著。结果表明，蜂蜜可使人体中柚皮苷/柚皮素的吸收显著降低33.4%，提示蜂蜜处理可能会改变柚皮的功效。
