Budd J M
School of Cognitive and Computing Sciences, University of Sussex, Brighton, UK.
Vis Neurosci. 2000 May-Jun;17(3):331-43. doi: 10.1017/s095252380017302x.
In the absence of a direct and specific marker for basket cells, the aim of this paper was to use available data to estimate the density of basket cell synaptic input to smooth and spiny neurons within layer IV of cat striate visual cortex (area 17). A linear quantitative analysis of layer IV basket cell connectivity data suggests that on average basket cells (1) comprise 25-35% of all GABAergic neurons in layer IV (3552-4736 cells mm(-3)), (2) account for 30-41% of all putative inhibitory dendritic synapses of layer IV spiny stellate cells (145-195 synapses cell(-1)) and a similar proportion of layer IV basket cells (25-37%, 71-107 synapses cell(-1)), and (3) provide each layer IV spiny cell with 13-45 axons and each layer IV basket cell with 6-29 axons. These estimates suggest that basket cells may be less common and provide a smaller proportion of the dendritic synaptic input to layer IV spiny and smooth neurons than previously thought. In addition, the analysis indicates that a layer IV spiny stellate cell may receive on average as many synapses and axons from layer IV basket cells as from lateral geniculate relay cells. Based on this potential numerical similarity, a geniculate-basket synaptic pairing in a spine-shaft microcircuit is hypothesized. This microcircuit could implement a type of local (dendritic) push-pull interaction underlying subfield antagonism.
由于缺乏针对篮状细胞的直接且特异性的标记物，本文旨在利用现有数据估算猫纹状视觉皮层（17区）IV层内篮状细胞对平滑神经元和棘状神经元的突触输入密度。对IV层篮状细胞连接性数据的线性定量分析表明，平均而言，篮状细胞：（1）占IV层所有GABA能神经元的25 - 35%（3552 - 4736个细胞/mm³）；（2）占IV层棘状星状细胞所有假定抑制性树突突触的30 - 41%（145 - 195个突触/细胞），IV层篮状细胞的比例与之相似（25 - 37%，71 - 107个突触/细胞）；（3）为每个IV层棘状细胞提供13 - 45条轴突，为每个IV层篮状细胞提供6 - 29条轴突。这些估计表明，篮状细胞可能比之前认为的更不常见，并且为IV层棘状神经元和平滑神经元提供的树突突触输入比例更小。此外，分析表明，IV层棘状星状细胞平均从IV层篮状细胞接收的突触和轴突数量可能与从外侧膝状体中继细胞接收的一样多。基于这种潜在的数值相似性，推测在棘 - 轴微回路中存在膝状体 - 篮状细胞突触配对。这种微回路可能实现一种局部（树突）推挽相互作用，构成子场拮抗的基础。
