Cytophysiology of spiny stellate cells in the striate cortex and their role in the excitatory mechanisms of intracortical synaptic circulation.

Spiny stellate cells (SS) are an exclusive category of cortical interneurons and are the major component of intracolumnar, lateral, and callosal excitation of pyramidal and non-pyramidal neurons in the neocortex. The axons of SS make contact with the apical dendrites of pyramidal neurons, forming cartridge-type en passant synapses with them. SS establish recurrent connections with inhibitory interneurons and other SS, and also form autapses contacts. SS subtypes were identified and descriptions of their structure, neurochemical specialization, and spatial organization in the human and animal neocortex are provided. The results of our own studies, along with published data, are used to form a critical analysis of current concepts of the histophysiology of recurrent excitatory and inhibitory neurocirculation in cortical modules.