Pepmueller P H, Moore T L
Division of Rheumatology and Pediatric Rheumatology, Saint Louis University Health Sciences Center, MO 63104, USA.
Curr Opin Rheumatol. 2000 Jul;12(4):269-73. doi: 10.1097/00002281-200007000-00006.
This paper reviews the recent literature on the juvenile spondyloarthropathies. Several case reports emphasized clinical characteristics of the spondyloarthropathies including reactive arthritis. MR imaging seemed to enhance the detection of sacroiliitis in children with spondyloarthropathies. The presence of different cytokines in various forms of juvenile arthritis including the juvenile spondyloarthropathies was investigated and suggested a role for the anti-inflammatory cytokines in milder disease. Evidence for the association of low-molecular-weight polypeptide gene polymorphism with susceptibility to acute anterior uveitis was found in a Mexican population of patients with spondyloarthropathies, including 80 with juvenile spondyloarthropathy. A review of therapeutic use of sulfasalazine in children with chronic arthritis, including those with juvenile spondyloarthropathy, concluded that it was safe and effective. Last, a study assessed aerobic fitness and physical activity in patients with juvenile spondyloarthropathy in remission and suggested a decline in physical fitness in older patients.
本文综述了近期关于青少年脊柱关节病的文献。几例病例报告强调了脊柱关节病的临床特征，包括反应性关节炎。磁共振成像似乎提高了对青少年脊柱关节病患儿骶髂关节炎的检出率。研究了包括青少年脊柱关节病在内的各种形式青少年关节炎中不同细胞因子的存在情况，并提示抗炎细胞因子在病情较轻的疾病中发挥作用。在墨西哥脊柱关节病患者群体（包括80例青少年脊柱关节病患者）中，发现了低分子量多肽基因多态性与急性前葡萄膜炎易感性之间的关联证据。一项关于柳氮磺胺吡啶在慢性关节炎患儿（包括青少年脊柱关节病患儿）中的治疗应用综述得出结论，该药安全有效。最后，一项研究评估了处于缓解期的青少年脊柱关节病患者的有氧适能和身体活动情况，结果表明老年患者的身体素质有所下降。
