Bilbrey G L, Faloona G R, White M G, Atkins C, Hull A R, Knochel J P
Ann Intern Med. 1975 Apr;82(4):525-8. doi: 10.7326/0003-4819-82-4-525.
Chronic renal failure in man is associated with hyperglucagonemia that is not corrected by hemodialysis. Plasma glucagon concentrations were measured in nine patients before and after renal transplantation. Mean plasma glucagon concentration in eight patients with chronic renal failure before transplantation was 295 plus or minus 171 pg/ml (plus or minus SD). After successful transplantation, mean plasma glucagon concentration fell to 134 plus or minus 81 pg/ml (plus or minus SD) (P less than 0.001). Plasma glucagon concentration remained elevated in an additional patient who received a cadaveric graft that never functioned. Immunologic rejection of transplanted kidneys was associated with a dramatic increase of plasma glucagon concentration.
人类慢性肾衰竭与高胰高血糖素血症相关，且血液透析无法纠正该病症。对9例患者在肾移植前后的血浆胰高血糖素浓度进行了测量。8例慢性肾衰竭患者在移植前的血浆胰高血糖素平均浓度为295±171 pg/ml（±标准差）。成功移植后，血浆胰高血糖素平均浓度降至134±81 pg/ml（±标准差）（P<0.001）。另一名接受了无功能尸体肾移植的患者，其血浆胰高血糖素浓度持续升高。移植肾的免疫排斥反应与血浆胰高血糖素浓度的显著升高有关。
