慢性肾衰竭时血浆腺嘌呤核苷酸水平升高及其可能的意义。

Elevated plasma adenine nucleotide levels in chronic renal failure and their possible significance.

作者信息

Moss A H, Solomons C C, Alfrey A C

出版信息

Proc Clin Dial Transplant Forum. 1979;9:184-8.

Abstract

Plasma ATP, ADP and AMP levels are increased in uremia. The elevation in plasma ATP level correlates with the serum creatinine in chronic renal failure patients not on dialysis. Successful renal transplantation is associated with the return of ATP, ADP and AMP levels to the normal range. Plasma ATP elevations may reflect sickness on the cellular level in uremia and measurement of plasma ATP may be a useful test to assess the need for dialysis. Plasma ATP elevations could also reflect underexcretion in the urine. Irrespective of the mechanism responsible for increased plasma ATP levels in uremia, an elevation of plasma ATP could have major physiological and metabolic consequences.

摘要

尿毒症患者血浆中三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和一磷酸腺苷（AMP）水平升高。在未接受透析的慢性肾衰竭患者中，血浆ATP水平的升高与血清肌酐相关。成功的肾移植与ATP、ADP和AMP水平恢复至正常范围有关。血浆ATP升高可能反映了尿毒症时细胞水平的病变，测定血浆ATP可能是评估透析需求的一项有用检测。血浆ATP升高也可能反映尿液排泄不足。无论导致尿毒症患者血浆ATP水平升高的机制如何，血浆ATP升高都可能产生重大的生理和代谢后果。