肿瘤血管生成因子与人类皮肤肿瘤

Tumor angiogenic factor and human skin tumors.

作者信息

Wolf J E, Hubler W R

出版信息

Arch Dermatol. 1975 Mar;111(3):321-7.

Abstract

A transparent acrylic hamster cheek-pouch chamber was used to investigate the elaboration of a tumor angiogenic factor (TAF) by human cutaneous neoplasms; direct tumor implantations, transfilter diffusion, and soluble tumor extracts were used in the study. A diffusible and filterable TAF was extracted from cutaneous tumors and produced distinctive patterns of sequential vasodilatation, tortuosity, and neovascular proliferation in the cheek-pouch membrane. Malignant human neoplasms (eg, melanoma, basal cell epithelioma, squamous cell carcinoma, lymphoma) produced striking neovascularization; vascular tumors (eg, Kaposi sarcoma, pyogenic granuloma, vascular histiocytoma) stimulated dramatic hyperemia and ectasia. Angiogenesis was conspicuously absent after implantation of control materials and nevoid or normal cutaneous components (with the exception of epidermis). Tumor angiogenic factor appears to induce direct stimulation of endothelial cell mitosis and may be essential for survival of nutritionally ravenous neoplastic tissues. The interference with TAF has therapeutic implications.

摘要

使用透明丙烯酸仓鼠颊囊腔室来研究人类皮肤肿瘤产生肿瘤血管生成因子（TAF）的情况；该研究采用了直接肿瘤植入、滤膜扩散和可溶性肿瘤提取物。从皮肤肿瘤中提取出一种可扩散且可过滤的TAF，它在颊囊膜中产生了一系列独特的血管扩张、迂曲和新生血管增殖模式。人类恶性肿瘤（如黑色素瘤、基底细胞上皮瘤、鳞状细胞癌、淋巴瘤）产生了显著的新生血管形成；血管肿瘤（如卡波西肉瘤、化脓性肉芽肿、血管组织细胞瘤）引发了明显的充血和扩张。植入对照材料以及痣样或正常皮肤成分（表皮除外）后，未出现明显的血管生成。肿瘤血管生成因子似乎能直接刺激内皮细胞有丝分裂，对于营养需求旺盛的肿瘤组织的存活可能至关重要。对TAF的干扰具有治疗意义。