Larsson L I, Sundler F, Håkanson R
Cell Tissue Res. 1975;156(2):167-71. doi: 10.1007/BF00221800.
HPP is the human counterpart of APP--a polypeptide that has been isolated from avian pancreas and shown to exert pronounced biological effects. The availability of anti-HPP serum enabled us to use immunohistochemical procedures for the localization of HPP in human pancreas. A small population of pancreatic islet cells showed strong immunofluorescence after staining with anti-HPP serum. The HPP cells were mainly localized at the periphery of the islets. Sometimes they were also seen scattered in the exocrine parenchyma as well as within the epithelium of small to medium-sized ducts. While rare in the pancreas of adult man, HPP cells were abundant in certain parts of the pancreas of foetuses (18-20 weeks gestational age). Their staining properties showed them to be distinct from the A, Band D cells of the pancreatic islets.
人胰多肽（HPP）是禽胰多肽（APP）的人类对应物——一种已从禽胰腺中分离出来并显示出具有显著生物学效应的多肽。抗人胰多肽血清的可得性使我们能够使用免疫组织化学方法在人胰腺中定位人胰多肽。一小部分胰岛细胞在用抗人胰多肽血清染色后显示出强烈的免疫荧光。人胰多肽细胞主要位于胰岛的周边。有时也可见它们散在于外分泌实质以及中小导管的上皮内。虽然在成年男性胰腺中很少见，但人胰多肽细胞在胎儿胰腺（妊娠18 - 20周）的某些部位大量存在。它们的染色特性表明它们与胰岛的A、B和D细胞不同。
