Adam D, Scholz H, Helmerking M
Department of Antimicrobial Therapy, Dr. v. Haunersches Children's Hospital, University of Munich, D-80337 Munich, Germany. D.Adam@kk-i. med.uni-muenchen.de.
J Infect Dis. 2000 Aug;182(2):509-16. doi: 10.1086/315709. Epub 2000 Jul 28.
A large-scale study with a 1-year follow-up was performed to compare 10 days of penicillin V with a short-course treatment (5 days) of other oral antibiotics in the treatment of group A beta-hemolytic streptococcus (GABHS) tonsillopharyngitis, to evaluate the efficacy and the incidence of poststreptococcal sequelae. The clinical response rates after completion of therapy were 94.5% in the 5-day group and 93.4% in the penicillin group (P<.001, equivalence test). The GABHS eradication rates were 83.3% in the 5-day group and 84.4% in the penicillin group (P=.022, equivalence test). Poststreptococcal sequelae were rare (5 patients) and did not occur in the context of this study. The efficacy of 5-day antibiotic regimens was equivalent to 10 days of penicillin V, but resolution of clinical symptoms was faster in the 5-day group (P<.001, Fisher's exact test). Recurrent tonsillopharyngitis occurs more frequently after treatment with penicillin (P=.03, Fisher's exact test).
开展了一项为期1年随访的大规模研究，比较10天青霉素V与其他口服抗生素短程治疗（5天）对A组β溶血性链球菌（GABHS）扁桃体咽炎的治疗效果，并评估链球菌感染后后遗症的发生率。治疗结束后的临床缓解率在5天治疗组为94.5%，青霉素组为93.4%（P<0.001，等效性检验）。GABHS清除率在5天治疗组为83.3%，青霉素组为84.4%（P=0.022，等效性检验）。链球菌感染后后遗症很少见（5例患者），在本研究中未出现。5天抗生素治疗方案的疗效与10天青霉素V相当，但5天治疗组临床症状缓解更快（P<0.001，Fisher精确检验）。青霉素治疗后复发性扁桃体咽炎更常见（P=0.03，Fisher精确检验）。
