Golstein P
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, 13288 Marseille Cedex 9, France.
Science. 2000 Jun 30;288(5475):2328-9. doi: 10.1126/science.288.5475.2328.
The binding of a ligand to its receptor has always been viewed as the trigger for signal transduction to ensue. However, as Golstein explains in his Perspective, new findings (Chan et al. and Siegel et al.) suggest that the Fas receptor preassembles into trimers without the help of its ligand, and that this preassembly conditions ligand binding, and thus subsequent signal transduction of a death signal.
配体与其受体的结合一直被视为信号转导随之发生的触发因素。然而，正如戈尔茨坦在其观点文章中所解释的，新的研究结果（陈等人以及西格尔等人的研究）表明，Fas受体在没有其配体帮助的情况下预先组装成三聚体，并且这种预先组装决定了配体的结合，从而决定了随后死亡信号的信号转导。
