Kelley W N
Nephron. 1975;14(1):99-115. doi: 10.1159/000180439.
A reduction in the serum urate concentration in hyperuricemic subjects can be achieved by increasing the renal excretion of uric acid, by inhibiting its synthesis, or by a combination of both modalities. The three most commonly used hypouricemic drugs are probenecid, sulfinpyrazone and allopurinol. Each drug has been considered in detail with regard to its mechanism of action, metabolism, diverse metabolic effects, side effects and interaction with other drugs. In addition, guidelines for the use of these drugs in hyperuricemic subjects are proposed.
通过增加尿酸的肾脏排泄、抑制尿酸合成或两者结合的方式，可以降低高尿酸血症患者的血清尿酸浓度。三种最常用的降尿酸药物是丙磺舒、磺吡酮和别嘌醇。已对每种药物的作用机制、代谢、各种代谢效应、副作用以及与其他药物的相互作用进行了详细研究。此外，还提出了在高尿酸血症患者中使用这些药物的指南。
