Kelley W N
Annu Rev Pharmacol. 1975;15:327-50. doi: 10.1146/annurev.pa.15.040175.001551.
In this review the drugs capable of increasing or lowering the serum urate concentration are considered with regard to mechanism of action and significance of the effect, where known. Several hypouricemic agents, probenecid, sulfinpyrazone, and allopurinol, are considered in further detail because of their major clinical importance. No effort has been made, however, to summarize the relative clinical indications for each agent. In addition, in those cases where specific details could not be included because of limitation of space, the appropiate reference has been given.
在本综述中，就已知的作用机制和效应的重要性而言，对能够升高或降低血清尿酸盐浓度的药物进行了探讨。几种降尿酸药物，如丙磺舒、磺吡酮和别嘌醇，因其主要的临床重要性而得到更详细的讨论。然而，并未对每种药物的相对临床适应证进行总结。此外，由于篇幅限制，在那些无法纳入具体细节的情况下，已给出了适当的参考文献。
