低毒性抗真菌药物合理设计的新方法。
Novel approaches in the rational design of antifungal agents of low toxicity.
作者信息
Borowski E
机构信息
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
出版信息
Farmaco. 2000 Mar;55(3):206-8. doi: 10.1016/s0014-827x(00)00024-0.
Abstract
This paper presents an overview of studies on novel strategies for the rational design of antifungal agents of low toxicity and overcoming the multidrug resistance (MDR) of fungi. This goal was achieved both due to the introduction of a novel target, glucosamine-6-phosphate synthase, as well as to the recognition of molecular basis of selectivity of action of amphotericin B derivatives.
摘要
本文概述了关于合理设计低毒抗真菌剂以及克服真菌多药耐药性（MDR）的新策略的研究。这一目标的实现既得益于引入了新的靶点——氨基葡萄糖-6-磷酸合酶，也得益于对两性霉素B衍生物作用选择性分子基础的认识。
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