农业用抗真菌剂：公共卫生的益友与劲敌。

Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP 14049-900, Brazil.

Department of Physiological Sciences, Health Sciences Centre, Federal University of Espirito Santo, Vitoria, ES 29047-105, Brazil.

Biomolecules. 2019 Sep 23;9(10):521. doi: 10.3390/biom9100521.

Fungal diseases have been underestimated worldwide but constitute a substantial threat to several plant and animal species as well as to public health. The increase in the global population has entailed an increase in the demand for agriculture in recent decades. Accordingly, there has been worldwide pressure to find means to improve the quality and productivity of agricultural crops. Antifungal agents have been widely used as an alternative for managing fungal diseases affecting several crops. However, the unregulated use of antifungals can jeopardize public health. Application of fungicides in agriculture should be under strict regulation to ensure the toxicological safety of commercialized foods. This review discusses the use of antifungals in agriculture worldwide, the need to develop new antifungals, and improvement of regulations regarding antifungal use.

真菌病在全球范围内被低估了，但它们对许多动植物物种以及公共卫生构成了重大威胁。近几十年来，全球人口的增加导致对农业的需求增加。因此，全球范围内都在努力寻找提高农业作物质量和生产力的方法。抗真菌剂已被广泛用作防治几种作物真菌病的替代方法。然而，抗真菌剂的不受管制使用会危及公共健康。农业中杀菌剂的应用应受到严格监管，以确保商业化食品的毒理学安全性。本综述讨论了全球农业中抗真菌剂的使用、开发新抗真菌剂的必要性以及改进抗真菌剂使用的法规。