Ajani U A, Gaziano J M, Lotufo P A, Liu S, Hennekens C H, Buring J E, Manson J E
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215-1204, USA.
Circulation. 2000 Aug 1;102(5):500-5. doi: 10.1161/01.cir.102.5.500.
An inverse association between moderate alcohol consumption and coronary heart disease (CHD) has been observed in several epidemiological studies. To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and without diabetes mellitus in a prospective cohort study.
A total of 87 938 US physicians (2790 with diagnosed diabetes mellitus) who were invited to participate in the Physicians' Health Study and were free of myocardial infarction, stroke, cancer, or liver disease at baseline were followed for an average of 5.5 years for death with CHD as the underlying cause. During 480 876 person-years of follow-up, 850 deaths caused by CHD were documented: 717 deaths among nondiabetic men and 133 deaths among diabetic men. Among men without diabetes at baseline, the relative risk estimates for those reporting rarely/never, monthly, weekly, and daily alcohol consumption were 1.00 (referent), 1.02, 0. 82, and 0.61 (95% CI 0.49 to 0.78; P for trend <0.0001) after adjustment for age, aspirin use, smoking, physical activity, body mass index, and history of angina, hypertension, and high cholesterol. Among men with diabetes at baseline, the relative risk estimates were 1.00 (referent), 1.11, 0.67, and 0.42 (95% CI 0.23 to 0.77; P for trend=0.0019).
These results suggest that light to moderate alcohol consumption is associated with similar risk reductions in CHD among diabetic and nondiabetic men.
多项流行病学研究观察到适度饮酒与冠心病（CHD）之间存在负相关。为评估糖尿病患者中是否存在类似关联，我们在一项前瞻性队列研究中，考察了有糖尿病和无糖尿病男性的轻度至中度饮酒与冠心病之间的关系。
共有87938名美国医生（其中2790名被诊断患有糖尿病）受邀参与医生健康研究，这些医生在基线时无心肌梗死、中风、癌症或肝病，随后以冠心病为潜在死因平均随访5.5年。在480876人年的随访期间，记录了850例由冠心病导致的死亡：非糖尿病男性中有717例死亡，糖尿病男性中有133例死亡。在基线时无糖尿病的男性中，在对年龄、阿司匹林使用情况、吸烟、体育活动、体重指数以及心绞痛、高血压和高胆固醇病史进行调整后，报告很少/从不饮酒、每月饮酒、每周饮酒和每日饮酒者的相对风险估计值分别为1.00（参照值）、1.02、0.82和0.61（95%可信区间0.49至0.78；趋势P<0.0001）。在基线时有糖尿病的男性中，相对风险估计值分别为1.00（参照值）、1.11、0.67和0.42（9
