美国男性医生适度饮酒与外周动脉疾病风险的前瞻性研究。
Prospective study of moderate alcohol consumption and risk of peripheral arterial disease in US male physicians.
作者信息
Camargo C A, Stampfer M J, Glynn R J, Gaziano J M, Manson J E, Goldhaber S Z, Hennekens C H
机构信息
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA.
出版信息
Circulation. 1997 Feb 4;95(3):577-80. doi: 10.1161/01.cir.95.3.577.
BACKGROUND
Moderate alcohol consumption decreases the risk of coronary heart disease, but its relation to peripheral arterial disease (PAD) is uncertain.
METHODS AND RESULTS
In the Physicians' Health Study, a randomized trial of the use of aspirin and beta-carotene in 22071 apparently healthy men, we documented 433 incident cases of PAD during 11 years of follow-up. After we controlled for age and treatment assignment, daily drinkers (> or = 7 drinks per week) had a relative risk (RR) of PAD of 0.92 (95% confidence interval, 0.72 to 1.17) compared with the reference group (< 1 drink per week). After additional control for smoking, however, the RR was 0.68 (0.52 to 0.89). Further control for exercise, diabetes mellitus, and parental history of myocardial infarction revealed an RR of 0.74 (0.57 to 0.97).
CONCLUSIONS
Moderate alcohol consumption appears to decrease the risk of PAD in apparently healthy men.
背景
适度饮酒可降低冠心病风险，但其与外周动脉疾病（PAD）的关系尚不确定。
方法与结果
在医师健康研究中，一项针对22071名表面健康男性使用阿司匹林和β-胡萝卜素的随机试验，我们在11年的随访中记录了433例PAD事件。在控制年龄和治疗分配后，与参考组（每周饮酒<1次）相比，每日饮酒者（每周≥7次）患PAD的相对风险（RR）为0.92（95%置信区间，0.72至1.17）。然而，在进一步控制吸烟因素后，RR为0.68（0.52至0.89）。进一步控制运动、糖尿病和心肌梗死家族史后，RR为0.74（0.57至0.97）。
结论
适度饮酒似乎可降低表面健康男性患PAD的风险。
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