Christie P J, Vogel J P
Dept of Microbiology and Molecular Genetics, The University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA.
Trends Microbiol. 2000 Aug;8(8):354-60. doi: 10.1016/s0966-842x(00)01792-3.
Several bacterial pathogens utilize conjugation machines to export effector molecules during infection. Such systems are members of the type IV or 'adapted conjugation' secretion family. The prototypical type IV system is the Agrobacterium tumefaciens T-DNA transfer machine, which delivers oncogenic nucleoprotein particles to plant cells. Other pathogens, including Bordetella pertussis, Legionella pneumophila, Brucellaspp. and Helicobacter pylori, use type IV machines to export effector proteins to the extracellular milieu or the mammalian cell cytosol.
几种细菌病原体在感染过程中利用接合机器输出效应分子。这类系统属于IV型或“适应性接合”分泌家族。典型的IV型系统是根癌土壤杆菌的T-DNA转移机器，它将致癌核蛋白颗粒传递到植物细胞中。其他病原体，包括百日咳博德特氏菌、嗜肺军团菌、布鲁氏菌属和幽门螺杆菌，利用IV型机器将效应蛋白输出到细胞外环境或哺乳动物细胞胞质溶胶中。
