Chen Z, Krug R M
Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.
Trends Microbiol. 2000 Aug;8(8):376-83. doi: 10.1016/s0966-842x(00)01794-7.
The NS1A protein of influenza A virus specifically inhibits the cellular machinery that processes the 3' ends of cellular pre-mRNAs by targeting two of the essential proteins of this machinery. Because the virus does not use this cellular machinery to synthesize the 3' poly(A) ends of viral mRNA, the nuclear export of cellular but not viral mRNAs is selectively inhibited.
甲型流感病毒的NS1A蛋白通过靶向该机制的两种必需蛋白，特异性抑制处理细胞前体mRNA 3'末端的细胞机制。由于病毒不利用这种细胞机制来合成病毒mRNA的3'多聚腺苷酸末端，因此细胞mRNA而非病毒mRNA的核输出被选择性抑制。
