Griem M L, Tokars R P, Petras V, Variakojis D, Baron J M, Griem S F
Cancer Treat Rep. 1979 Apr;63(4):655-7.
In a comprehensive mycosis fungoides program, 60 patients have been seen with a pathologic diagnosis of this disease. Forty-four patients with advanced disease were referred for radiation therapy. Three treatment techniques were identified in which 14 patients were treated with localized fields using electrons or whole-body electron-beam therapy with doses of less than 3000 rads, 21 patients were treated using the Stanford technique with tissue doses of between 3000 and 4000 rads, and nine patients were treated with six cycles of mechlorethamine, vincristine, prednisone, and procarbazine or cyclophosphamide, vincristine, prednisone, and procarbazine following the electron-beam therapy. The actuarial survival rate was 45% at 1 year for the 14 patients with localized electron-beam therapy, whereas the actuarial survival rates were 83% for patients treated with whole-body electron-beam therapy and 100% for patients treated with whole-body electron-beam therapy followed by four-drug chemotherapy. The recurrence-free interval for these three groups correlates with these observations. A central nervous system recurrence has been observed in the combined-therapy group.
在一项蕈样肉芽肿综合治疗项目中，已确诊60例该疾病患者。44例晚期患者接受了放射治疗。确定了三种治疗技术，其中14例患者采用电子束局部照射或全身电子束治疗，剂量小于3000拉德；21例患者采用斯坦福技术，组织剂量在3000至4000拉德之间；9例患者在电子束治疗后接受六个周期的氮芥、长春新碱、泼尼松和丙卡巴肼或环磷酰胺、长春新碱、泼尼松和丙卡巴肼治疗。14例接受局部电子束治疗的患者1年实际生存率为45%，而接受全身电子束治疗的患者实际生存率为83%，接受全身电子束治疗后再进行四联化疗的患者实际生存率为100%。这三组的无复发生存期与这些观察结果相关。联合治疗组观察到有中枢神经系统复发。
