Lei J, Li L, Xu A
Shandong Provincial Epidemic Prevention Center, Jinan.
Zhonghua Liu Xing Bing Xue Za Zhi. 1998 Dec;19(6):327-9.
Wild poliovirus has not been isolated in Shandong province since Apr. 1991. However, 71 clinically polio cases were diagnosed by an expert group, including 50 potential Vaccine Associated Paralytic Poliomyelitis (VAPP) including 31 having the sabin strain in the stools, from 1993 to 1996. The overall frequency of VAPP was one case per 1.25 million doses distributed. The relative frequencies of first dose in the OPV series was one case per 218,800 doses vs one case per 1.01 million for second dose. Based on data from the 31 cases, we estimated that the rates had been one case per 438,000 first dose and one case per 6.42 million second dose and one case per 10.44 million among the contacts of the cases. This results seemed to be higher than from other reports. Clinically confirmed poliomyelitis cases in Shandong were diagnosed by the experts group. The classification of clinical polio cases is important in the polio eradication program.
自1991年4月以来，山东省未分离出野生脊髓灰质炎病毒。然而，1993年至1996年，一个专家组诊断出71例临床脊髓灰质炎病例，其中包括50例潜在的疫苗相关麻痹性脊髓灰质炎（VAPP），其中31例粪便中有萨宾株。VAPP的总体发生率为每分发125万剂出现1例。口服脊髓灰质炎疫苗（OPV）系列中首剂的相对发生率为每218,800剂出现1例，而第二剂为每101万剂出现1例。根据31例病例的数据，我们估计首剂发生率为每43.8万剂出现1例，第二剂为每642万剂出现1例，病例接触者中为每1044万剂出现1例。这一结果似乎高于其他报告。山东省临床确诊的脊髓灰质炎病例由专家组诊断。临床脊髓灰质炎病例的分类在脊髓灰质炎根除计划中很重要。
