Bailly J L, Béguet A, Chambon M, Henquell C, Peigue-Lafeuille H
UFR Médecine, Laboratoire de Virologie, F-63002, Clermont-Ferrand Cedex 1, France.
J Clin Microbiol. 2000 Aug;38(8):2889-92. doi: 10.1128/JCM.38.8.2889-2892.2000.
We investigated six cases of enterovirus infection in a neonatal unit. The index patient, a 5-day-old boy, was admitted with aseptic meningitis due to echovirus 30 (E30). Secondary infections with E30 occurred in five babies. Comparison of the complete VP1 sequences showed that the isolates recovered from the index patient and his mother were closely related to those recovered from the five babies with secondary infections, demonstrating a nosocomial transmission of the virus. In the phylogenetic tree reconstructed from the VP1 sequences, the isolates formed a monophyletic cluster related to an E30 strain collected in June 1997 during an outbreak of aseptic meningitis.
我们对一家新生儿病房的6例肠道病毒感染病例进行了调查。首例患者是一名5日龄男婴,因埃可病毒30型(E30)感染导致无菌性脑膜炎入院。另外5名婴儿发生了E30继发感染。对完整的VP1序列进行比较后发现,从首例患者及其母亲身上分离出的病毒株与从5例继发感染婴儿身上分离出的病毒株密切相关,表明该病毒存在医院内传播。在根据VP1序列重建的系统发育树中,这些分离株形成了一个单系簇,与1997年6月无菌性脑膜炎暴发期间收集的一株E30毒株相关。