Inner Mongolia Center for Disease Control and Prevention, Huhhot, 010031, People's Republic of China.
WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory of biosafety, National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
Virol J. 2021 Jun 6;18(1):118. doi: 10.1186/s12985-021-01590-4.
An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China.
To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis.
A total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E30), which dominated transmission in China. To date, two E30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E30 before 2002.
We identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, and found that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E30 evolution and persistence over time in China.
2016 年 6 月至 8 月，中国内蒙古自治区发生无菌性脑膜炎疫情。
为明确其流行病学特征、病原体及可能的来源，采集标本进行病毒分离鉴定及分子流行病学分析。
2016 年 6 月 1 日至 8 月 31 日共临床诊断病例 363 例，发病高峰为 6 月 22 日至 7 月 17 日，占 63.1%（229/363），发病年龄以 6～12 岁儿童为主，占 68.9%（250/363）。本研究所有病毒分离株均属于肠道病毒 30 型（E30）C 基因型，为我国优势流行株。目前，我国已鉴定出 E30 存在 2 个传播株系，其中以株系 2 为主。E30 遗传多样性呈波动变化，2002 年后株系 2 导致 E30 遗传多样性增加，而株系 1 则对 2002 年前 E30 遗传多样性有重要影响。
本研究明确了 2016 年内蒙古无菌性脑膜炎疫情的流行病学及病原学原因，发现株系 2 在中国近年来的疫情中发挥了重要作用。同时，我们发现甘肃省可能在 E30 的传播中发挥了重要作用，可能是 E30 的起源地之一。此外，福建省、山东省、台湾省和浙江省在中国 E30 的进化和持续存在过程中也发挥了重要作用。
