Robey T C, Välimaa T, Murphy H S, Tôrmâlâ P, Mooney D J, Weatherly R A
Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Mott Hospital, Ann Arbor, MI 48109-0241, USA.
Arch Otolaryngol Head Neck Surg. 2000 Aug;126(8):985-91. doi: 10.1001/archotol.126.8.985.
To design and develop a biodegradable tracheal stent that can be used internally to stabilize and support surgically reconstructed airways.
In vitro mechanical and degradative properties of 80:20 poly(D,L-lactide-co-glycolide) (PLGA) "finger-like" stents were determined. The stents were then tested in vivo in rabbits that underwent anterior patch tracheoplasties with fascia lata grafts. Comparisons were made between a control group and an internal stent group for stridor development, overall group mortality, reconstructed airway lumen size, and histological findings.
Twenty-five New Zealand white rabbits.
The average dry modulus for the internal stents was 6800 kPa. All of the internal stents cracked by 4 weeks in buffer solution. Significant mass loss was not noted in vitro until after 5 weeks in buffer solution. By 14 weeks, the stents were nearly 100% degraded. The attrition rate for the control group was 23% compared with 17% for the experimental group. The stridor rate for the control group was also higher at 38% compared with 17% for the stented group. The stented rabbits had a significantly smaller average stenosis (23%) across the entire reconstruction site than the control group (34%) (P<.05).
Biodegradable PLGA stents degrade in a predictable fashion and have a statistically significant effect in augmenting anterior patch tracheoplasties with fascia lata grafts in rabbits.
设计并开发一种可生物降解的气管支架，用于在体内稳定和支撑手术重建的气道。
测定了80:20聚（D，L-丙交酯-共-乙交酯）（PLGA）“指状”支架的体外力学和降解性能。然后在接受阔筋膜移植前路补片气管成形术的兔子体内对支架进行测试。比较了对照组和内置支架组在喘鸣发生、总体组死亡率、重建气道管腔大小和组织学结果方面的差异。
25只新西兰白兔。
内置支架的平均干模量为6800 kPa。所有内置支架在缓冲溶液中4周时出现破裂。在缓冲溶液中5周后体外才出现明显的质量损失。到14周时，支架几乎100%降解。对照组的损耗率为23%，而实验组为17%。对照组的喘鸣发生率也更高，为38%，而支架组为17%。置入支架的兔子在整个重建部位的平均狭窄程度（23%）明显小于对照组（34%）（P<0.05）。
可生物降解的PLGA支架以可预测的方式降解，并在增强兔子阔筋膜移植前路补片气管成形术中具有统计学上的显著效果。
